About RADIESSE^® Volumizing Filler

Thank you for your interest in RADIESSE^® Volumizing Filler, the FDA-approved injectable filler that is aiming to become the standard for the correction of moderate to severe facial wrinkles and folds such as nasolabial folds. RADIESSE Volumizing Filler has long been used for vocal fold augmentation, maxillofacial augmentation, and radiographic tissue marking, and has become a premier dermal filler for aesthetic uses. To learn more about this product, visit the following pages:

Treatment with RADIESSE Volumizing Filler is unique because it utilizes a calcium-based microsphere technology to provide immediate volume restoration and stimulates the body to produce new collagen.¹ Something no other filler does. RADIESSE Volumizing Filler is safe and long lasting, giving your patients the convenience and longevity they desire.

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Begin your journey to a more refreshed you today. Find a local RADIESSE^® provider to help you restore what time has taken away.

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Manufactured by Merz Aesthetics, Inc.
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The Merz Aesthetics logo is a trademark of Merz Pharma GmbH & Co. KGaA.
RADIESSE is a registered trademark of Merz Aesthetics, Inc

Important RADIESSE Volumizing Filler Treatment Considerations
RADIESSE Volumizing Filler is FDA-approved for subdermal implantation for the correction of moderate to severe facial wrinkles and folds, such as nasolabial folds. After injection, patients may experience redness, bruising, swelling or other local side effects. Most side effects of treatment resolve within a few days. More rare side effects may include swelling that lasts longer, unevenness or firmness in the area injected, and as with any injection, there may be a risk of infection.

¹ Berlin A, Hussain M, Goldberg D. (2008) Calcium Hydroxylapatite Filler for Facial Rejuvenation: A Histologic and Immunohistochemical Analysis. Dermatologic Surgery, Volume 34, S64-S67.

² Bass LS, Smith S, Busso M, McClaren M. (2010) Calcium Hydroxylapatite (Radiesse) for Treatment of Nasolabial Folds: Long-Term Safety and Efficacy Results, Aesthetic Surgery Journal, 30 (2), 235-238.

³ Moers-Carpi MM, Opi Tufet J. Calcium Hydroxylapatite (RADIESSE^®) versus Nonanimal Stabilized Hyaluronic Acid (Restylane^®) for the Correction of Nasolabial Folds: a 60 patient, 12-Month, Multicenter, Prospective, Randomized, Controlled, Split-Face Trial. Dermatol Surg 2008;34: 210-215.

⁴ Moers-Carpi M, Vogt S, Martinez Santos B, Planas J, Rovira Vallves S, and Howell DJ. A Multicenter, Randomized Trial Comparing Calcium Hydroxylapatite (RADIESSE^®) to Two Hyaluronic Acids (Juvéderm^® and Perlane^®) for Treatment of Nasolabial Folds. 205 Patients. Dermatol Surg, 2007; 33: S144-S151.

⁵ Based on a clinical study of 50 patients. Split face treatments of RADIESSE Volumizing Filler alone and RADIESSE Volumizing Filler mixed with 2% lidocaine were given to patients. Significant pain reduction is defined as a 2 point reduction on the Visual Analog Scale (VAS). Data on file.

⁶ Sundaram H, Voigts B, Beer K, Meland M. (2010) Comparison of the Rheological Properties of Viscosity and Elasticity in Two Categories of Soft Tissue Fillers: Calcium Hydroxylapatite and Hyaluronic Acid, Dermatol Surg, 36 (s3), 1859-1865.

About RADIESSE® Volumizing Filler

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About RADIESSE^® Volumizing Filler