Clinical Publications

Bass LS, Smith S, Busso M, McClaren M. Calcium Hydroxylapatite (Radiesse) for Treatment of Nasolabial Folds: Long-Term Safety and Efficacy Results, Aesthetic Surgery Journal 2010; 30 (2), 235-238.
Marmur E, Green L, Busso M. Controlled, Randomized Study of Pain Levels in Subjects Treated with Calcium Hydroxylapatite Premixed with Lidocaine for Correction of Nasolabial Folds. Dermatologic Surgery 2010; 36 (3), 309-315
Sundaram H, Voigts B, Beer K, Meland M. Comparison of the Rheological Properties of Viscosity and Elasticity in Two Categories of Soft Tissue Fillers: Calcium Hydroxylapatite and Hyaluronic Acid, Dermatologic Surgery 2010; 36 (s3), 1859-1865.
Voigts R, Devore D, Grazer J. Dispersion of Calcium Hydroxylapatite Accumulations in the Skin: Animal Studies and Clinical Practices 2010; Dermatologic Surgery, 36 (S1), 798-803.
Marmur ES, Taylor SC, Grimes PE, Boyd CM, Porter JP. Six-month safety results of calcium hydroxylapatite (Radiesse) for treatment of nasolabial folds in Fitzpatrick Skin Types of IV-VI. Dermatologic Surgery 2009; 35(S2), 1641-1645.
Berlin, AL, Hussain, M, Goldberg, DJ. "Calcium Hydroxylapatite Filler for Facial Rejuvenation: A Histologic and Immunohistochemical Analysis." Dermatological Surgery 2008; 34:S64-67.
Carruthers, A and Carruthers J, Liebeskind, M and Forster, B. "Radiographic and computed tomographic studies of calcium hydroxylapatite for treatment of HIV-associated facial lipoatrophy and correction of nasolabial folds." Dermatological Surgery 2008; 34:S78-84.
Coleman, KM, Voigts, R, DeVore, DD, Termin, P and Coleman, WP III. "Neocollagenesis after injection of calcium hydroxylapatite composition in a canine model." Dermatological Surgery 2008; 34: S53-S55.
Moers-Carpi, M and Tufet JO. "Calcium hydroxylapatite versus stabilized hyaluronic acid for the correction of nasolabial folds: a 12-month, multicenter, prospective, randomized, controlled, split-face trial." Dermatologic Surgery 2008; 34:210-215.
Alam, M and Yoo, SS. "Technique for calcium hydroxylapatite injection for correction of nasolabial fold depressions." Journal of the American Academy of Dermatology 2007; 56(2):285-289.
Moers-Carpi, M, Vogt, S, Santos, BM, Planas, J, Vallve, SR and Howell, DJ. "A multicenter, randomized trial comparing calcium hydroxylapatite to two hyaluronic acids for treatment of nasolabial folds." Dermatologic Surgery 2007; 33:S144-S151.
Schweiger, ES, Riddle, CC, Wernli, BJ and Tonkovic-Capin, V. "Comparison of poly-l-lactic acid and calcium hydroxylapatite for treating human Immunodeficiency virus-associated facial lipoatrophy." Cosmetic Dermatology 2007. 20(5): 304-312.
Smith, S, Busso, M, McClaren, M and Bass, LS. "A randomized, bilateral, prospective comparison of calcium hydroxylapatite microspheres versus human-based collagen for the correction of nasolabial folds." Dermatologic Surgery 2007; 33:S112-S121.
Silvers, SL, Eviatar, JA, Echavez, MI and Pappas, AL. "Prospective open label 18-month trial of calcium hydroxylapatite (RADIESSE) for facial soft tissue augmentation in patients with HIV-associated lipoatrophy: One year durability." Plastic and Reconstructive Surgery Journal 2006; 118(3 Suppl):34S-45S.
Eviatar JA, Silvers, SL and Echavez, MI. "Restorative treatment of HIV-Associated Facial Lipoatrophy." Plastic and Reconstructive Surgery 2005. 116(Suppl).
Comite, SL, Liu, JF, Balasubramanian, S and Christian, MA. "Treatment of HIV-associated facial lipoatrophy with Radiance FN™ (RADIESSE™)." Dermatology Online Journal 2004;10(2):2. http://dermatology.cdlib.org/102/therapy/HIV/comite.html
Marmur, ES, Phelps, R and Goldberg, DJ. "Clinical, histologic and electron microscopic findings after injection of a calcium hydroxylapatite filler." Journal of Cosmetic Laser Therapy 2004; 6:223-226.

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Important RADIESSE Volumizing Filler Treatment Considerations
RADIESSE Volumizing Filler is FDA-approved for subdermal implantation for the correction of moderate to severe facial wrinkles and folds, such as nasolabial folds. After injection, patients may experience redness, bruising, swelling or other local side effects. Most side effects of treatment resolve within a few days. More rare side effects may include swelling that lasts longer, unevenness or firmness in the area injected, and as with any injection, there may be a risk of infection.

¹ Berlin A, Hussain M, Goldberg D. (2008) Calcium Hydroxylapatite Filler for Facial Rejuvenation: A Histologic and Immunohistochemical Analysis. Dermatologic Surgery, Volume 34, S64-S67.

² Bass LS, Smith S, Busso M, McClaren M. (2010) Calcium Hydroxylapatite (Radiesse) for Treatment of Nasolabial Folds: Long-Term Safety and Efficacy Results, Aesthetic Surgery Journal, 30 (2), 235-238.

³ Moers-Carpi MM, Opi Tufet J. Calcium Hydroxylapatite (RADIESSE^®) versus Nonanimal Stabilized Hyaluronic Acid (Restylane^®) for the Correction of Nasolabial Folds: a 60 patient, 12-Month, Multicenter, Prospective, Randomized, Controlled, Split-Face Trial. Dermatol Surg 2008;34: 210-215.

⁴ Moers-Carpi M, Vogt S, Martinez Santos B, Planas J, Rovira Vallves S, and Howell DJ. A Multicenter, Randomized Trial Comparing Calcium Hydroxylapatite (RADIESSE^®) to Two Hyaluronic Acids (Juvéderm^® and Perlane^®) for Treatment of Nasolabial Folds. 205 Patients. Dermatol Surg, 2007; 33: S144-S151.

⁵ Based on a clinical study of 50 patients. Split face treatments of RADIESSE Volumizing Filler alone and RADIESSE Volumizing Filler mixed with 2% lidocaine were given to patients. Significant pain reduction is defined as a 2 point reduction on the Visual Analog Scale (VAS). Data on file.

⁶ Sundaram H, Voigts B, Beer K, Meland M. (2010) Comparison of the Rheological Properties of Viscosity and Elasticity in Two Categories of Soft Tissue Fillers: Calcium Hydroxylapatite and Hyaluronic Acid, Dermatol Surg, 36 (s3), 1859-1865.

Clinical Publications

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